Closed-Loop Modulation of a Notch-Filter Stimulation Strategy for Tremor Management with a Neuroprosthesis

Tremor is the most common movement disorder, and one of the major causes of functional disability. In spite of the existence of various treatments, tremor is not managed effectively in a large number of patients, which make it a major cause of loss of quality of life. Here we present a novel strategy for tremor suppression through neurostimulation that replicates an adaptive notch-filter at the frequency of the tremor. The controller, which adapts the neurostimulation to the ongoing amplitude, frequency and phase of the tremor, is implemented in a wearable neuroprosthesis for tremor management. Experimental results in one patient with severe essential tremor illustrate the interest of the approach. Keywords— Tremor, Neurostimulation, Essential tremor, Neuroprosthesis, Electromechanical delay